作者：Jim Kling 齣處：WebMD醫學新聞 　　November 14, 2008 （華盛頓西雅圖訊）－根據一項新發錶在美國過敏、氣喘與免疫學2008年會的研究結果顯示 Leptin濃度上升 Leptin濃度增加與氣喘有關 - 趣味新聞網

發表日期 2008-11-23T08:03:57+08:00

     作者：Jim Kling
齣處：WebMD醫學新聞

November 14, 2008 （華盛頓西雅圖訊）－根據一項新發錶在美國過敏、氣喘與免疫學2008年會的研究結果顯示，Leptin濃度上升與氣喘嚴重度有關。

Leptin這個荷爾濛在控製食慾與促進發炎上扮演重要角色。肥胖病患經常看到Leptin抵抗性，這些病患可能因肥胖相關的氣喘所苦。流行病學研究顯示，肥胖病患的氣喘嚴重度與發作頻率較高。

過去的研究結果顯示高血中Leptin濃度與氣喘之間的關係，但是並未顯示齣清楚的關連性。

在這項斷麵性與觀察性研究中，病患根據身體質量指數（BMI）以及氣喘嚴重度分組。這項研究收納瞭49位病患，其中75%是女性。他們被進一步分成三組：氣喘且營養不良患者（第一組；共17位）、15位氣喘且體重過重患者（第二組，共15位）、以及氣喘且肥胖患者（第三組，共17位）。

平均Leptin濃度第一組為6.7 ng/dL、第二組為9.3 ng/dL，而第三組為19.4 ng/dL。第一組與第三組以及第二組與第三組之間的Leptin濃度差異達到統計上顯著程度（P<.05）。研究者也檢驗Leptin濃度與疾病活性之間的關係。中等嚴重度氣喘的值為8.9 ng/dl，那些輕度持續性氣喘的濃度為14.5 ng/dl，而中度持續性氣喘的濃度為18.9 ng/dl（P<.05）。

主要研究者、墨西哥市國傢醫療中心過敏與免疫學的住院醫師U. Garcia-Ramirez嚮Medscape過敏與臨床免疫學錶示，氣喘在極端肥胖病患身上是很常見的，這項研究顯示，Leptin濃度過高與氣喘嚴重度上升有關，他推測降低病患的BMI也可以降低氣喘嚴重度。

座談會引言人賓州大學醫學與小兒科教授Timothy Craig醫師錶示，這項研究結果顯示，氣喘病患可以透過減重來維持健康；過去的研究結果並不一緻，但這些研究顯示它是有關聯性的。他嚮Medscape過敏與臨床免疫學錶示，讓病患減重是值得一試的方法。

此外，Craig醫師與其他現場參與者錶示，這些結果並不代錶Leptin濃度與氣喘之間的因果關係；這兩種情況都可以是其病因，這是個雞或是蛋的問題。

這項研究並未接受商業贊助。Garcia-Ramirez醫師與Craug醫師錶示沒有相關資金上的往來。

Increased Leptin Levels Linked to Asthma

By Jim Kling
Medscape Medical News

November 14, 2008 (Seattle, Washington) — Increased serum leptin levels correspond to asthma severity, according to a new study presented here at the American College of Allergy, Asthma & Immunology 2008 Annual Meeting.

The hormone leptin plays important roles in controlling appetite and promoting inflammation. Leptin resistance is commonly observed in obese patients, who can suffer from obesity-related asthma. Epidemiologic studies suggest that the frequency and severity of asthma is higher in obese people.

Previous studies have considered a potential link between high serum leptin levels and asthma, but a clear relationship has not been demonstrated.

In new study, which was cross-sectional and observational, patients were grouped according to body mass index (BMI) and also stratified by asthma severity. The study included 49 patients, 75% of whom were women. They were divided into 3 groups: asthmatic eutrophic patients (group 1, n = 17), 15 asthmatic overweight patients (group 2, n = 15), and asthmatic obese patients (group 3, n = 17).

Mean leptin serum concentrations were 6.7 ng/dL, 9.3 ng/dL, and 19.4 ng/dL in group 1, group 2, and group 3, respectively. The differences in leptin levels were statistically significant between groups 1 and 3 and between groups 2 and 3 (P < .05). The researchers also linked serum concentrations of leptin to disease activity. Patients with intermittent asthma had values of 8.9 ng/dL, those with mild persistent asthma had levels of 14.5 ng/dL, and moderately persistent asthma patients had 18.9 ng/dL (P < .05).

Asthma is common in extremely obese patients, lead investigator U. Garcia-Ramirez, MD, a resident in allergy and immunology at National Medical Center, Mexico City, told Medscape Allergy & Clinical Immunology. This study "suggests that high serum leptin concentrations [are associated with] an increase in asthma severity." He speculated that reducing a patient's BMI could also reduce asthma severity.

The results suggest that asthma patients could be well served by losing weight, said session moderator Timothy Craig, DO, professor of medicine and pediatrics at Penn State University. "Previous studies are conflicting, but this suggests that there is a correlation. It's probably worth the effort" to get the patient to lose weight, he told Medscape Allergy & Clinical Immunology.

Still, he and others in attendance noted that the results do not demonstrate a causative link between leptin levels and asthma; an underlying condition could be contributing to both. "It's a question [of which came first], the bird or the egg," said Dr. Craig.

The study did not receive commercial support. Dr. Garcia-Ramirez, and Dr. Craig have disclosed no relevant financial relationships.

American College of Allergy, Asthma & Immunology (ACAAI) 2008 Annual Meeting: Abstract 5. Presented November 9, 2008.

[ 本帖最後由 goodcat1111 於 2008-11-23 21:35 編輯 ]

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